Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm

• DOI: 10.14314/polimery.2025.3.4
• Publication Date: 2025-03-31T08:40:33Z
• Authors: Mohsen Safaei; Farnoosh Khaleseh; Saba Ahmadi; Mohammad Salmani ...; Douglas Law; Ling Shing Wong; Dachepalli Ravinder; Amos Nhlapo; Mohd Hashim; Azra Parveen

To determine the optimal conditions for obtaining poly(lactic-co-glycolic) acid with selenium (PLGA/selenium) nanocomposites the Taguchi method was used. FT-IR, Raman spectroscopy, XRD and FESEM analysis confirmed the nanocomposites’ structure. The nanocomposite containing 6 mg/mL of selenium obtained in the process where the mixing time was 75 min showed the highest antibacterial activity against Streptococcus mutans. The obtained nanocomposites are an innovative approach to improving oral health and can be used as antibacterial materials for medical and dental applications.