Is Dementia More Fatal Than Previously Estimated? A Population-based Prospective Cohort Study

• DOI: 10.14336/ad.2018.0123
• Publication Date: 2018-12-13T08:32:53Z
• Authors: Jong Bin Bae; Ji Won Han; Kyung Phil Kwak; Bong Jo Kim; Shin Gyeom Kim; Jeong Lan Kim; Tae Hui Kim; Seung-Ho Ryu; Seok Woo Moon; Joon Hyuk Park; Jong Chul Youn; Dong Young Lee; Dong Woo Lee; Seok Bum Lee; Jung Jae Lee; Jin Hyeong Jhoo; Ki Woong Kim
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 16. Peace & justice; Orginal Article; 3. Good health

Dementia increases the risk of mortality (ROM) in elderly and estimates hazard ratio (HR) dementia for have ranged from 1.7 to 6.3. However, previous studies may underestimated ROM due length bias, which occurs when failing include persons with rapidly progressive diseases, who died before they could be included study. This population-based prospective cohort study conducted on 6,752 randomly sampled Koreans, aged 60 years or older (the Korean Longitudinal Study Cognitive Aging Dementia). disorders were evaluated at baseline 2-year follow-up using version Consortium Establish a Registry Alzheimer's Disease Assessment Packet (CERAD-K), prevalent incident cases identified. The participants' deaths confirmed through National Mortality Database Statistics Korea. We compared between dementia, estimated HR Cox proportional hazards model. Of 5,097 responders assessment, 150 participants had (prevalent dementia), 95 developed during period (incident dementia). was about 3 times higher than those (HR = 3.04, 95% confidence interval [CI] 1.34-6.91). Compared cognitively normal both assessments, approximately 8 8.37, % CI 4.23-16.54). In conclusion, much more fatal previously estimated. clinical settings, warrants attention physicians, particularly recently cases.