Premature CD4+ T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome

• DOI: 10.14336/ad.2020.0203
• Publication Date: 2020-11-21T17:09:10Z
• Authors: Ming Cao; Lei Ruan; Yi Huang; Jinli Wang; Jinhua Yan; Yu Sang; Shanshan Li; Guan Wang; Xiaofen Wu
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Orginal Article; 3. Good health

Acquired immune responses mediated by CD4+ T cells contribute to the initiation and progression of acute coronary syndrome (ACS). ACS patients show acquired system abnormalities that resemble characteristics autoimmune dysfunction described in elderly. This study aimed investigate role premature senescence underlying mechanism. We compared immunological status 25 patients, 15 young healthy individuals (C1), 20 elderly with absence (C2). The percentages lymphocyte subsets (including naïve, regulatory, memory effector cells) peripheral blood were analyzed. In a significant expansion CD4+CD28null decline CD4+CD25+CD62L+Treg observed. addition, showed an accelerated loss CD4+CD45RA+CD62L+ naïve compensatory increase number CD4+CD45RO+ cells. demonstrated no difference frequency cell receptor excision circles (TRECs) age-matched volunteers. expression p16Ink4a was increased while CD62L decreased patients. Compared donors, lowest telomerase activity both CD4+CD28+and serum levels C-reactive protein, Cytomegalovirus IgG, Helicobactor pylori IgG Chlamydia pneumonia significantly higher results suggested percentage subpopulations correlated chronic infection, which contributes immunosenescence. conclusion, infection induced CD4+T cells, may be responsible for development ACS.