Risks of mortality for various phenotypes in patients with type 2 diabetes mellitus in the Novosibirsk region

• DOI: 10.14341/dm13195
• Publication Date: 2025-02-21T08:52:24Z
• Authors: I. A. Bondar; O. Y. Shabelnikova
• Keywords: diabetes mellitus type 2; RC620-627; phenotype; risk factors; clusters; Nutritional diseases. Deficiency diseases; mortality

BACKGROUND : Type 2 diabetes mellitus (T2DM) is a disease with high prevalence and early mortality, identifying groups at risk for adverse outcomes important in secondary prevention. AIM To study clinical, metabolic genetic factors deaths various clinical phenotypes patients type the Novosibirsk region. MATERIALS AND METHODS: A prospective cohort was conducted of 2507 T2DM. The follow-up duration 6.3±2.5 years. Depending on level C-peptide HOMA-IR index, were divided into 3 phenotypes: insulinopenic (n=288), classic (n=1921), insulin-resistant (n=298). Fatal outcome period from 2014 to 31.12.2022 recorded 592 (23.6%). DNA isolation genotyping structural variants TCF7L2(rs7903146), ATM(rs11212617) genes performed by PCR. RESULTS main cause death T2DM all CVD (63.8%). Patients an phenotype had significantly shorter time death, 12.3±5.5 years, compared (p<0.001). Risk mortality causes according multivariate Cox regression analysis (OR) (1.043, p<0.001), HbA1c (1.131, creatinine (1.013, p=0.002), T allele TCF7L2(rs7903146) gene (OR=1.431, p=0.017) C ATM(rs11212517) (OR=1.509, p=0.007). Predictors cardiovascular (OR=1.129, p=0.001), (OR=1.041, (OR=1.015, p=0.004), (OR=1.719, p=0.005) ATM (OR=1.539, p=0.024). CONCLUSION: found that poor prognosis. predictor general HbA1c. increased overall 43.1%, 50.9%.