Long non-coding RNA XIST promotes the malignant features of oral squamous cell carcinoma (OSCC) cells through regulating miR-133a-5p/VEGFB.

• DOI: 10.14670/hh-18-504
• Publication Date: 2023-01-01
• Authors: Kankui Wu; Wancui Wu; Mengxuan Wu; Wenzhe Liu
• Keywords: XIST

Oral squamous cell carcinoma (OSCC) represents a frequently seen oral cavity malignancy, and the mechanisms of its occurrence development remain unclear. The present work examined expression biological function long non-coding RNA (lncNRA) XIST (X-inactive specific transcript) in OSCC cells tissues.A total number 50 paired non-carcinoma tissue samples were collected this study. Gene levels cancer tissues quantified by RT-qPCR. In addition, gain- loss-of-function experiments conducted to investigate roles as well downstream targets cells.XIST was upregulated tissues, which predicted poorer prognostic outcome patients. Silencing inhibited growth invasion triggered apoptosis. miR-133a-5p identified target XIST, downregulated tissues. mediated effect targeting VEGFB. VEGFB overexpression rescued inhibitory effects silencing on growth, migration.Taken together, above data indicates that serves an oncogenic factor enhance miR-133a/VEGFB axis.