Expression and hypermethylation of JAM and EPB41L3 in cervical squamous cell carcinoma: Clinical significance and applications.

• DOI: 10.14670/hh-18-697
• Publication Date: 2024-08-01
• Authors: Yun Gu; Chengzhuo Chu; Bei Yuan; Jiandong Wang; Shiyang Pan
• Keywords: Clinical Significance

This study aimed to explore the expression and hypermethylation of EPB41L3 JAM3 in cervical squamous cell carcinoma (CSCC) investigate their clinical significance. mRNA was analyzed using a public database, protein detected immunohistochemistry. The methylation status CSCC tissues cytological specimens quantitative methylation-specific PCR (qMSP). were downregulated CSCC. positively 39.4% frequently expressed those with lower FIGO stage no lymph node metastasis. 18.9% tissues. 52.3% related higher 72.7% older ages In specimens, found normal or inflamed epithelial cells. 0%, 8.3%, 6.3% ASCUS, LSIL, HSIL samples, while 12.5%, 42.9%, 71.4%, respectively. sensitivity combination detection 15.6%, 85.7%, specificity 100%. Downregulation by are potential biomarkers for cancer screening.