A Brief History of Steroid Therapy for Guillain-Barré Syndrome

• DOI: 10.14704/nq.2017.15.3.1074
• Publication Date: 2018-09-12T08:08:26Z
• Authors: Xing Ning; Yin Liyong; Lan Xifa
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Steroids have been used for the treatment of Guillain-Barre Syndrome (GBS) since 1950s, while their clinical efficacy remains poorly defined. Most randomized controlled trials after 1970s yielded no clues significant differences between steroid therapy and symptomatic supportive therapy, adjusting factors that affected biases, reanalysis two with largest number samples among them showed intravenous methylprednisolone was superior to or its combination immunoglobulin exhibited effects. To date, there is still strong evidence proving denying high-dose methylprednisolone, further studies are merited issues regarding steroids GBS.