The utilization of serum thrombopoietin levels as an early biomarker in determining severe acute biliary pancreatitis

• DOI: 10.14744/tjtes.2024.23583
• Publication Date: 2025-03-04T08:43:30Z
• Authors: Ahmet Sencer Ergin

This study aimed to evaluate the efficacy of thrombopoietin (TPO), a growth factor and acute-phase reactant, as an early prognostic marker for predicting disease severity in patients with acute biliary pancreatitis. A total 72 pancreatitis admitted Ankara Numune Training Research Hospital, General Surgery Department, were included study. The was classified using 2012 Revised Atlanta Classification, blood samples collected from each patient within first six hours hospitalization measure TPO levels. levels then compared C-reactive protein (CRP) other scoring systems. According found be statistically significant distinguishing severe moderate mild cases. When evaluating sensitivity specificity ratios serum pancreatitis, value 81.61 pg/dL identified, 86.6% 69% specificity. In our study, accuracy detecting Balthazar system had highest precision (area under curve [AUC]: 0.905) receiver operating characteristic (ROC) analysis (95% confidence interval). Serum identified second strongest predictors (AUC: 0.831). These findings suggest that is valuable indicator However, further randomized studies larger cohorts are still required.