Immunomodulatory roles of CTRP3 in endotoxemia and metabolic stress

• DOI: 10.14814/phy2.12735
• Publication Date: 2016-03-20T21:37:36Z
• Authors: Pia S. Petersen; Risa M. Wolf; Xia Lei; Jonathan M. Peterson; G. William Wong
• Keywords: CCL11; Proinflammatory cytokine

C1q/TNF-related protein 3 (CTRP3) is a secreted hormone that modulates hepatic glucose and lipid metabolism. Its circulating levels are reduced in human rodent models of obesity, metabolic state accompanied by chronic low-grade inflammation. Recent studies have demonstrated an anti-inflammatory role for recombinant CTRP3 attenuating LPS-induced systemic inflammation, its deficiency markedly exacerbates inflammation mouse model rheumatoid arthritis. We used genetic to explore the immunomodulatory function response acute (LPS challenge) (high-fat diet) inflammatory stimuli. In sublethal dose LPS challenge, neither nor overexpression transgenic mice had impact on IL-1β, IL-6, TNF-α, or MIP-2 induction at serum mRNA levels, contrary previous findings based administration. context, we measured 71 cytokine wild-type fed high-fat diet matched control low-fat diet. On diet, elevated multiple chemokines (CCL11, CXCL9, CXCL10, CCL17, CX3CL1, CCL22 sCD30). However, when obesity was induced with lower IL-5, sVEGF2, sVEGFR3, higher level soluble gp130. Contingent upon state, altered chemokine lean mice, attenuated setting insulin resistance. These results highlight context-dependent CTRP3.