miRNAs as markers for the development of individualized training regimens: A pilot study

0301 basic medicine 0303 health sciences Physiology individual training adaptation Pilot Projects Original Articles Adaptation, Physiological microRNAs MicroRNAs 03 medical and health sciences physical exercise QP1-981 Humans Female skeletal muscle Muscle, Skeletal Exercise Biomarkers
DOI: 10.14814/phy2.15217 Publication Date: 2022-03-11T12:40:07Z
ABSTRACT
Small, non-coding RNAs (microRNAs) have been shown to regulate gene expression in response to exercise in various tissues and organs, thus possibly coordinating their adaptive response. Thus, it is likely that differential microRNA expression might be one of the factors that are responsible for different training responses of different individuals. Consequently, determining microRNA patterns might be a promising approach toward the development of individualized training strategies. However, little is known on (1) microRNA patterns and their regulation by different exercise regimens and (2) possible correlations between these patterns and individual training adaptation. Here, we present microarray data on skeletal muscle microRNA patterns in six young, female subjects before and after six weeks of either moderate-intensity continuous or high-intensity interval training on a bicycle ergometer. Our data show that n = 36 different microRNA species were regulated more than twofold in this cohort (n = 28 upregulated and n = 8 downregulated). In addition, we correlated baseline microRNA patterns with individual changes in VO2 max and identified some specific microRNAs that might be promising candidates for further testing and evaluation in the future, which might eventually lead to the establishment of microRNA marker panels that will allow individual recommendations for specific exercise regimens.
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