miRNAs as markers for the development of individualized training regimens: A pilot study

• DOI: 10.14814/phy2.15217
• Publication Date: 2022-03-11T12:40:07Z
• Authors: Manuel Widmann; Felipe Mattioni M...; Christof Burgstahler; Gunnar Erz; Philipp Schellhorn; Annunziata Fragasso; Angelika Schmitt; Andreas M. Nieß; Barbara Munz
• Keywords: Adaptive response

Small, non-coding RNAs (microRNAs) have been shown to regulate gene expression in response exercise various tissues and organs, thus possibly coordinating their adaptive response. Thus, it is likely that differential microRNA might be one of the factors are responsible for different training responses individuals. Consequently, determining patterns a promising approach toward development individualized strategies. However, little known on (1) regulation by regimens (2) possible correlations between these individual adaptation. Here, we present microarray data skeletal muscle six young, female subjects before after weeks either moderate-intensity continuous or high-intensity interval bicycle ergometer. Our show n = 36 species were regulated more than twofold this cohort (n 28 upregulated 8 downregulated). In addition, correlated baseline with changes VO2max identified some specific microRNAs candidates further testing evaluation future, which eventually lead establishment marker panels will allow recommendations regimens.