Breaking down the recovery of O2 pathway: Peripheral extraction recovery pattern defines exercise capacity and clinical outcomes

• DOI: 10.14814/phy2.70337
• Publication Date: 2025-04-14T06:47:56Z
• Authors: Ahmed El Shaer; Mariana Garcia‐Ar...; Anas Abed; Shannon Heffernan; Yuning Wang; Tashfeen Javed; Amirhossein Esmaeeli; Abdul Wahab Arif; Ran Tao; Naga Dharmavaram; James Runo; Jill N. Barnes; Farhan Raza

Abstract Poor recovery pattern of oxygen consumption (V̇O 2 ) post‐exercise is associated with adverse clinical outcomes. However, it remains unknown which component the O pathway (Fick principle) defines this prognostic risk, for example, peripheral extraction, stroke volume, heart rate. Retrospective cohort study included 120 participants (heart failure preserved ejection fraction: HFpEF = 68, pre‐capillary pulmonary hypertensio n 31, non‐cardiac dyspnea 21). Percent metrics were calculated as percent reduction each hemodynamic variable from peak exercise to recovery, (exercise‐recovery)/exercise ×100%. Overall, mean age (standard deviation) was 62.6 (14.4) years and 54% females. Among three groups (HFpEF, hypertension, dyspnea), patterns components statistically non‐significant. Peripheral extraction ( r 0.43, p < 0.001) rate 0.25, correlated V̇O , but only remained significant in multivariate analysis 0.01). (<41%; median) demonstrated poor one‐year survival mortality hospitalizations (HR 2.82; CI 95% 1.38–5.74, 0.003). most Physiologically, elucidates importance skeletal muscle vascular function.