Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia

• DOI: 10.1503/jpn.090049
• Publication Date: 2010-03-30T17:17:07Z
• Authors: Bjørn H. Ebdrup; Birte Glenthøj; Hans Rasmussen; Bodil Aggernaes; Annika R. Langkilde; Olaf B. Paulson; Henrik Lublin; Arnold Skimminge; William Baaré
• Keywords: Caudate nucleus

<h3>Background:</h3> Enlarged ventricles and reduced hippocampal volume are consistently found in patients with first-episode schizophrenia. Studies investigating brain structure antipsychotic-naive have generally focused on the striatum. In this study, we examined whether ventricular enlargement caudate reductions morphological traits of <h3>Methods:</h3> We obtained high-resolution 3-dimensional <i>T</i>₁-weighted magnetic resonance imaging scans for 38 schizophrenia 43 matched healthy controls by use a 3-T scanner. warped images to each other high-dimensional intersubject registration algorithm. performed voxel-wise group comparisons permutation tests. small correction hippocampus, false discovery rate (<i>p</i> &lt; 0.05) control multiple comparisons. derived analyzed estimates volumes. grouped as those (<i>n</i> = 9) or without 29) any lifetime substance abuse examine possible effects abuse. <h3>Results:</h3> that volumes were decreased no enlargement, differences global significant associations between tissue duration untreated illness psycho-pathology. The appeared be influenced history Exploratory analyses indicated nucleus accumbens <h3>Limitations:</h3> This study was not priori designed test abuse, subgroup small. <h3>Conclusion:</h3> Reductions may constitute patients. However, clinical implications these findings unclear. Moreover, past accentuate reduction. Magnetic studies addressing potential warranted.