CCR5-Δ32 polymorphism: a possible protective factor for post-stroke depressive symptoms

• DOI: 10.1503/jpn.200197
• Publication Date: 2021-07-22T11:55:21Z
• Authors: Oren Tene; Hen Hallevi; Jeremy Molad; Saly Usher; Estelle Seyman; Natan M. Bornstein; Shani Shenhar-Tsa...; Einor Ben Assayag
• Keywords: Stroke

A naturally occurring loss-of-function mutation in the gene for C-C chemokine receptor type 5 (CCR5-Δ32) has recently been reported as a protective factor post-stroke motor and cognitive recovery. We sought to examine whether this also prevented development of depressive symptoms up 2 years after stroke.Participants were survivors first-ever mild moderate ischemic stroke or transient attack from TABASCO prospective study who underwent 3 T MRI at baseline examined by multiprofessional team 6, 12 24 months event, including an evaluation using Geriatric Depression Scale.CCR5-Δ32 status depression available 435 patients. Compared with noncarriers, CCR5-Δ32 carriers (16.1%) had fewer admission (p = 0.035) 6 < 0.001), 0.001) 0.006) index event. This association remained significant adjustment age, sex, education, antidepressant use, ethnicity presence cortical infarcts. These findings more robust women. baseline, noncarriers tended remain stable grow worse over time, but carriers, improve.A limitation was exclusion patients severe pre-stroke depression.Carriers allele lower tendency develop post-stroke, phenomenon prominent could have clinical implications; they suggest mechanism-based treatment target depression. Drugs mimicking exist serve novel therapy.