Elevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: a new disorder of glucose tolerance

• DOI: 10.1507/endocrj.ej12-0079
• Publication Date: 2012-10-24T22:43:03Z
• Authors: Ceyda Kabaroglu; Betül Ersoy; Ece Onur; Bayram Özhan; Soner Erdin; Ahmet Var; Oya Bayindir; Gönül Dinç
• Keywords: Neopterin; Glucose tolerance test; Glucose Metabolism Disorder

We observed glucose levels >140 mg/dL measured at 30 minutes (min) during an oral tolerance test (OGTT) in some obese patients. aimed to investigate the significance of this finding by comparing lipid profiles, insulin resistance indices, and systemic inflammatory mediators between adolescents with normal (NGT), impaired (IGT), elevated min. The study involved 80 (body mass index >95(th) percentile for age sex) (48 female, 32 male) 11 16 years age. Depending on OGTT results, patients were divided into NGT IGT groups. third group was recruited from as having > 140 minutes. Lipid [interleukin-6 (IL-6)], neopterin, lipoprotein associated phospholipase A₂ (Lp-PLA₂)] assessed. Neopterin Lp-PLA₂ significantly higher compared those both groups (p=0.013, 0.004, respectively). In these adolescents, IL-6 only than (p=0.01). logistic regression analysis, IL-6, neopterin detected be related high blood min (OR 1.11, p=0.01; OR 9.03, p=0.013; 1.01, p=0.004 Obese demonstrated levels, which atherosclerotic indicators, IGT. These results suggest that may a new disorder obesity.