Association between DNA methylation levels of <i>thioredoxin-interacting protein (TXNIP)</i> and changes in glycemic traits: a longitudinal population-based study

• DOI: 10.1507/endocrj.ej23-0629
• Publication Date: 2024-03-27T22:15:04Z
• Authors: Keisuke Maeda; Ryosuke Fujii; Hiroya Yamada; Eiji Munetsuna; Mirai Yamazaki; Yoshitaka Ando; Genki Mizuno; Hiroaki Ishikawa; Koji Ohashi; Yoshiki Tsuboi; Yuji Hattori; Yuya Ishihara; Nobuyuki Hamajima; Shuji Hashimoto; Koji Suzuki
• Keywords: dNaM; Thioredoxin-Interacting Protein

Thioredoxin-interacting protein (TXNIP) plays an important role in glucose metabolism, and its expression is regulated by DNA methylation (DNAm). Although the association between TXNIP DNAm type 2 diabetes mellitus has been demonstrated studies with a cross-sectional design, prospective are needed. We therefore examined levels longitudinal changes glycemic traits conducting study involving 169 subjects who underwent two health checkups 2015 2019. used pyrosequencing assay to determine leukocytes (cg19693031). Logistic regression analyses were performed assess associations dichotomized marked increases traits. At four years, hypomethylation group had higher percentage of fasting plasma (FPG) hemoglobin A1c (HbA1c) compared those hypermethylation group. The adjusted odds ratios for FPG HbA1c significantly than found that at baseline was associated increase Leukocyte status could potentially be as early biomarker impaired homeostasis.