Tracheobronchomalacia Is Associated with Increased Morbidity in Bronchopulmonary Dysplasia

• DOI: 10.1513/annalsats.201702-178oc
• Publication Date: 2017-06-16T17:32:54Z
• Authors: Erik B. Hysinger; Nicholas L. Friedman; Michael A. Padula; Russell T. Shinohara; Huayan Zhang; Howard B. Panitch; Steven M. Kawut; Jaqueline Evans; Francine Dykes; Anthony Piazza; Gregory Sysyn; Carl Coghill; Ramasubbareddy Dh...; Anne Hansen; Karna Murthy; Kristina Reber; Rashmin Savani; Theresa Grover; Girija Natarajan; Jonathan Nedrelow; Annie Chi; Stephen Welty; Eugenia Pallotto; Becky Rodgers; Robert Lyle; Lisa Kelly; Steven Chin; David Durand; Jeanette Asselin; Priscilla Joe; Jacquelyn Evans; Michael Padula; Beverly Brozanski; Joan Rosenbaum; Tasmin Najaf; Amit Mathur; Rakesh Rao; Victor McKay; Mark Speziale; Billie Short; Kevin Sullivan; Donald Null; Robert DiGeronimo; Michael Uhing; Lynne Willett; John Grebe; Rajan Wadhawan
• Keywords: Tracheobronchomalacia; Bronchopulmonary Dysplasia

Tracheobronchomalacia is a common comorbidity in neonates with bronchopulmonary dysplasia. However, the effect of tracheobronchomalacia on clinical course dysplasia not well-understood.We sought to assess impact outcomes large, multi-center cohort.We preformed cohort study 974 admitted 27 neonatal intensive care units participating Children's Hospital Neonatal Database who had undergone bronchoscopy. In hospital morbidity for and (N=353, 36.2%) was compared those without (N=621, 63.8%) using mixed-effects multivariate regression.Neonates more comorbidities, such as gastroesophageal reflux (OR=1.65, 95%CI 1.23- 2.29, P=0.001) pneumonia (OR=1.68, 1.21-2.33, P=0.002) commonly required surgeries tracheostomy (OR=1.55, 1.15-2.11, P=0.005) gastrostomy (OR=1.38, 1.03-1.85, P=0.03) tracheobronchomalacia. Neonates were hospitalitized (118 ± 93 vs 105 83 days, P=0.02) ventilated (83.1 91.1 67.2 71.9 P=0.003) longer than Upon discharge, BPD likely be mechanically (OR=1.37, 95CI 1.01-1.87 P=0.045) possibly less receive oral nutrition (OR=0.69, 0.47-1.01, P=0.058).Tracheobronchomalacia undergo bronchoscopy associated complicated hospitalizations.