Association of Sodium with Obstructive Sleep Apnea. The ELSA-Brasil Study

• DOI: 10.1513/annalsats.202005-498oc
• Publication Date: 2020-10-22T17:44:22Z
• Authors: Soraya Giatti; Ronaldo B. Santos; Aline N. Aielo; Wagner A. Silva; Barbara K. Parise; Silvana P. Souza; Andrea Pio-Abreu; Luiz A. Bortolotto; Paulo A. Lotufo; Isabela M. Bensenor; Luciano F. Drager
• Keywords: Urine sodium; Apnea–hypopnea index

Rationale: Excessive sodium may have a role in the pathogenesis of obstructive sleep apnea (OSA) for patients with hypervolemic conditions, but it is unclear whether this valid all OSA, including those no significant comorbidities.Objectives: To test association urinary and OSA large sample participants from ELSA-Brasil (Estudo Longitudinal de Saúde do Adulto-Brasil) Study. In addition, we stratified analysis according to presence hypertension.Methods: cross-sectional study, was defined by an apnea-hypopnea index ≥15 events/h. A validated 12-hour urine collection as representative 24-hour period obtained measure excretion. We performed logistic regression excretion (dependent variable) adjusting age, sex, race income, glomerular filtration rate, diabetes, physical activity, antihypertensive classes related address potential residual factors that influence excretion, additional replacing salt intake (food frequency questionnaire) using same models.Results: studied 1,946 (age 49 ± 8 yr; 43.4% men). third them had OSA. Compared presented higher (1.66 [1.19-2.29] vs. 1.99 [1.44-2.69] g/12 h; P < 0.001). After adjustments confounding factors, found overall associations (odds ratio [OR], 1.09; 95% confidence interval [CI], 0.97-1.23; = 0.150). Regardless status, hypertensive than normotensive (1.93 [1.35-2.64] 1.71 [1.22-2.37] h). An independent observed hypertension only (OR, 1.326; CI, 1.067-1.648; 0.011), interaction not (P 0.37). The revealed consistent findings.Conclusions: seems be modest limited and, consequently, fluid retention such hypertension.