Comparison of High-Flow Nasal Cannula and Conventional Oxygen Therapy for High-Risk Patients During Bronchoscopy Examination: A Multi-Center Randomized Controlled Trial

• DOI: 10.1513/annalsats.202410-1109oc
• Publication Date: 2025-03-19T20:03:12Z
• Authors: Hao Qin; Jie Li; Jun Wang; Yu-Guang Yang; Guo-Qiang Jing; Rong-Zhang Chen; Wei Tan; Yong-Qi Zhang; Tian Li; Jun-Ci Yang; Bing Dai; Qin Wang; Yang Jiao; Yang Xia; Hai-Dong Huang; Qiang Li; Yu-Chao Dong; Chong Bai; Wei Zhang
• Keywords: Nasal cannula; Oxygen therapy

Despite the increasing use of high-flow nasal cannula (HFNC) oxygen therapy during endoscopy examination, its impact on high-risk patients remains uncertain. we aimed to compare HFNC and conventional (COT) bronchoscopy in at for desaturation (morbid obesity, narrow trachea, or baseline hypoxemia and/or hypercapnia). In this multicenter randomized controlled trial (RCT), scheduled presenting with any factors were randomly assigned receive COT after providing written consent. Vital signs, pulse oximetry (SpO2), transcutaneous carbon dioxide (PtCO2) continuously monitored. The occurrence (SpO2≤90% lasted >10s), frequency examination interruption treatment escalation compared between groups. Of 148 initially enrolled patients, six withdrew, leaving 72 70 groups, respectively. Most had airway stenosis. significantly reduced (34.7 vs. 61.4%, p=0.016), fewer instances (26.4 58.6%, p<0.001) less frequent (30.6 57.1%, p=0.001). During lowest SpO2 was higher (94[IQR, 87-98] vs 87.5[79-93]%, p=0.001), while highest PtCO2 lower (64.6[56.8-70.1] 68.3[62.3-77.0] mmHg, p=0.04). No significant differences observed regarding time first desaturation, withdrawal, durations other adverse events a population predominantly stenosis, occurrence, interruption, patients. Clinical registration available www.ChiCTR.org.cn, ID: ChiCTR2100055038.