Comprehensive search for cysteine cathepsins in the human genome

• DOI: 10.1515/bc.2004.040
• Publication Date: 2004-08-23T11:59:41Z
• Authors: A. Rossi; Q. Deveraux; B. Turk; A. Sali
• Keywords: Pseudogene; Cathepsin L; Cathepsin H; Cathepsin A; Cathepsin L1; Cathepsin E

Our study was aimed at examinating whether or not the human genome encodes for previously unreported cysteine cathepsins. To this end, we used analyses of sequence and mRNA expression levels. The program TBLASTN employed to scan draft 11 known cathepsin-like segments in were inspected, filtered, annotated. In addition cathepsins, identified three pseudogenes, closely related cathepsin L, on chromosome 10, as well two remote homologs, tubulointerstitial protein antigen antigen-related protein. No new members family identified. profiles 10 cathepsins showed varying levels 46 different tissues cell lines. any L-like pseudogenes found. Based these results, it is likely that date all are known.