Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome

• DOI: 10.1515/cclm-2017-0502
• Publication Date: 2017-11-22T22:16:07Z
• Authors: Hui Shi; Hui Zheng; Yu-Feng Yin; Qiong-Yi Hu; Jia-Lin Teng; Yue Sun; Hong-Lei Liu; Xiao-Bing Cheng; Jun-Na Ye; Yu-Tong Su; Xin-Yao Wu; Jin-Feng Zhou; Gary L. Norman; Hui-Yun Gong; Xin-Ming Shi; Yi-Bing Peng; Xue-Feng Wang; Cheng-De Yang
• Keywords: Lupus anticoagulant; Immunoglobulin M

Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were examined. IgG IgM aPS/PT, IgG/IgM/IgA anticardiolipin (aCL) anti-β 2 -glycoprotein I (anti-β2GPI) tested by ELISA. Results: sixty (86.0%) positive for at least one aPS/PT isotype. thirty five (72.6%) 124/186 (66.7%) 99 (53.2%) both. Approximately half SNAPS and/or aPS/PT. Highly significant between venous thrombotic events (odds ratio [OR]=6.72) IgG/IgM (OR=9.44) found. Levels significantly different manifestations those fetal (p=0.014). association anticoagulant (LAC) highly (p<0.001). When both positive, OR 101.6. Notably, 91.95% (80/87) LAC-positive specimens suggesting is an effective option when LAC testing not available. Conclusions: Anti-PS/PT antibody assays demonstrated high diagnostic performance APS, detected some negative criteria markers may serve as potential risk predictors obstetric complications.