Acute-phase dynamics and prognostic value of growth differentiation factor-15 in ST-elevation myocardial infarction

• DOI: 10.1515/cclm-2018-1189
• Publication Date: 2019-02-01T11:03:13Z
• Authors: Ferran Rueda; Josep Lupón; Cosme García-García; German Cediel; M. Cruz Aranda Ne...; Judith Serra Gregori; Carlos Labata; Teresa Oliveras; Marc Ferrer; Oriol de Diego; Jordi Serra; Elena Revuelta López; Antoni Bayés-Genís
• Keywords: GDF15

Abstract Background Growth differentiation factor 15 (GDF-15) in ST-elevation myocardial infarction (STEMI) is prognostic first-generation radioimmunoassays. We examined GDF-15 temporal dynamics STEMI and its predictive value using a first fully automated electrochemiluminescence assay. Methods In this prospective study, circulating concentration was measured at admission (0 h), 12 h 24 1026 consecutive patients treated between February 2011 May 2016 with primary percutaneous coronary intervention. h, h) (30 days 3 years) were examined. Results Median 1443 pg/mL 0 1731 1510 (p<0.001). During follow-up, 94 died (9.2%) 154 (15.0%) hospitalized. strong predictor of 30-day mortality (hazard ratio [HR] 1.76, 95% confidence interval [CI], 1.33–2.34 h; HR 2.99 [95% CI, 2.18–4.09] 1.97 1.47–2.63] multivariable Cox proportional hazards models. improved discrimination reclassification clinical risk model. also associated 3-year (HR 1.31 1.04–1.65] 1.42 1.10–1.84] 1.51 1.16–1.96] composite cardiovascular hospitalization 1.17 1.01–1.37] 1.20 1.02–1.42] 1.27 1.08–1.50] h). Conclusions peaked remained elevated STEMI. measurement during the valuable for predicting especially short- but long-term outcomes, may be useful addition to stratification.