COVID-19 infections are also affected by human ACE1 D/I polymorphism

• DOI: 10.1515/cclm-2020-0425
• Publication Date: 2020-04-17T13:15:09Z
• Authors: Joris R. Delanghe; Marijn M. Speeckaert; Marc L. De Buyzere
• Keywords: 0303 health sciences; Polymorphism, Genetic; Haptoglobins; SARS-CoV-2; Vitamin D-Binding Protein; Pneumonia, Viral; COVID-19; Complement C3; Peptidyl-Dipeptidase A; 3. Good health; Betacoronavirus; 03 medical and health sciences; INDEL Mutation; Prevalence; Humans; Coronavirus Infections; Hemochromatosis Protein; Pandemics

The number of victims of the COVID-19 pandemic shows important geographical differences. In this study, a number of human genetic polymorphisms were compared to the number of Covid-19 patients and Covid-19 mortality. Data from 33 countries were analyzed. Among the polymorphisms tested, the human angiotensine converting enzyme (ACE) polymorphism turned out to be a determinant factor in both prevalence and mortality. The present findings may partly explain why some countries are more affected than others by the Covid-19 pandemic.