A NEW SERIES OF 1-PHENYLPYRAZOLE PEPTIDOMIMETICS

• DOI: 10.1515/hc.1999.5.5.407
• Publication Date: 2011-05-04T10:52:36Z
• Authors: Luciene M. F. Santos; Antonio J. Alves; Dalci J. Brondani; Antonio R. de Faria; Antonio C. C. Fre...; José G. de Lima; Ana C. Lima Leite
• Keywords: Peptidomimetic

A facile and efficient method for the synthesis of a new series 1-phenylpyrazole peptidomimetics 6a-f is described.Peptide bond formation between unsaturated carboxylic acid amino residue has been achieved using benzotriazolyloxy-tris-(dimethylamino) phosphonium hexafluorophosphate (BOP) reagent triethylamine (TEA).This strategy was found to be successful obtaining pyrazole peptidomimetics.