SYNTHESIS AND BIOLOGICAL EVALUATION OF 1H-PYRAZOLO [3,4-b] PYRIDINE-5 CARBOXYLIC ACIDS AGAINST VACCINIA VIRUS

• DOI: 10.1515/hc.2002.8.5.427
• Publication Date: 2011-05-04T11:23:39Z
• Authors: Alexandre R. Azevedo; Vitor F. Ferreira; Heloisa de Mello; Luiz R. Leão-Ferr...; Alfredo V. Jabor; Izabel C.P.P. Fru...; Helena S. Pereira; Nissin Moussatche; Alice M. Rolim Be...
• Keywords: 01 natural sciences; 0104 chemical sciences

Several new 3-phenyl and 3-alky 1-l//-pyrazolo[3,4-Z>]pyridine derivatives (3a-e) were prepared evaluated against Vaccinia virus on BSC-40 cells.The 3a, 3b 3d showed an inhibitory activity above 90% at 30 μΜ, 40 μΜ 50 concentrations.