Thyroid Hormone Levels and their Relationship to Survival in Children with Bacterial Sepsis and Septic Shock

• DOI: 10.1515/jpem.2004.17.10.1435
• Publication Date: 2011-04-15T11:17:35Z
• Authors: D. Yıldızdaş; N. Önenli-Mungan; Η. Yapıcıoğlu; A.K. Topaloglu; Y. Sertdemir; B. Yüksel
• Keywords: Free thyroxine

Reported studies have showed alternations of thyroid hormones in critical illness mostly adults and some children. In this study, we aimed to measure hormone levels children with sepsis septic shock investigate the relationship these clinical state survival.Thyroid shock, age- sex-matched controls were measured.There 51 (group S), 21 SS) 30 control C) group. Total triiodothyronine (TT3) (nmol/l): 0.91 +/- 0.22, 0.64 0.23, 2.11 0.59; free (FT3) (pmol/l): 0.027 0.006, 0.018 0.007, 0.049 0.010; total thyroxine (TT4) 100.62 21.93, 65.79 19.35, 109.65 19.35; (FT4) 18.06 3.87, 10.32 1.29, 19.35 3.87; stimulating (TSH) (mIU/ml): 5.0 2.0, 4.8 2.4, 5.2 3.0, sepsis, controls, respectively. The TT3, FT3, TT4, FT4 group SS significantly lower than those groups S C. TT3 FT3 C, but there was no significant difference between TSH slightly decreased both not significant. Eleven (21.6%) 15 (71.4%) died (p < 0.001). TT4 markedly non-survivors compared survivors 0.001).These changes hypothalamo-pituitary-thyroidal axis may suggest a possible prognostic value shock. To best our knowledge, report is first study compare large number patients healthy childhood.