Catch-up Growth in Severe Juvenile Hypothyroidism: Treatment with a GnRH Analog
Adult
Male
2. Zero hunger
Adolescent
Patient Selection
Puberty
Growth
Weight Gain
Body Height
Drug Administration Schedule
Body Mass Index
Gonadotropin-Releasing Hormone
Thyroxine
03 medical and health sciences
0302 clinical medicine
Hypothyroidism
Age Determination by Skeleton
Humans
Drug Therapy, Combination
Female
Child
Retrospective Studies
DOI:
10.1515/jpem.2004.17.3.345
Publication Date:
2011-04-15T11:36:07Z
AUTHORS (7)
ABSTRACT
Anecdotal reports suggest that the addition of a gonadotropin releasing hormone (GnRH) analog (GnRHa) in addition to L-thyroxine (LT4) replacement may increase adult stature in children with severe longstanding hypothyroidism by prolonging the pubertal growth period. This retrospective chart review compares the height outcome and body mass index in 33 children (21 treated with LT4 alone and 12 treated with LT4 + GnRHa) with severe longstanding hypothyroidism and bone age delay. Seventeen controls and six GnRHa-treated patients were followed to adult height (BA >14 yr [F]/16 yr [M] and/or growth velocity < 2 cm/yr). At diagnosis, GnRHa-treated patients were 1) older and shorter for chronological age, and 2) more advanced in puberty and bone age. Despite these differences, at adult height, both groups had similar improvements in height Z scores, similar height deficits, and comparable adult heights. Changes in BMI Z score were similar for both groups. Our study suggests that the addition of GnRHa to LT4 may improve interval growth without imposing a risk of obesity in children with longstanding severe hypothyroidism.
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