Comparative analysis of clinical, biochemical and genetic aspects associated with bone mineral density in small for gestational age children

• DOI: 10.1515/jpem.2011.196
• Publication Date: 2011-06-29T12:24:48Z
• Authors: Liliana Silvano; Mirta Miras; Adriana Pérez; Gabriela Picotto; Gabriela Díaz de ...; Liliana Muñoz; Silvia Martin; Gabriela Sobrero; Pedro Armelini; Verónica Mericq; Nori Tolosa de Ta...
• Keywords: Male; 0301 basic medicine; gene polymorphism; Collagen Type I; small for gestational age; 03 medical and health sciences; Child Development; Bone Density; Insulin-Like Growth Factor II; Humans; Insulin-Like Growth Factor I; Child; Genetic Association Studies; Growth Disorders; Glycoproteins; Infant, Newborn; IGF system; Collagen Type I, alpha 1 Chain; Bone Diseases, Metabolic; Early Diagnosis; Insulin-Like Growth Factor Binding Protein 3; Child, Preschool; Infant, Small for Gestational Age; Female; bone mineral density; Carrier Proteins

Clinical, biochemical and genetic analysis related to bone mineral density (BMD) were carried out in children born small for gestational age (SGA) that failed to achieve postnatal catch-up growth (CUG), SGA children that completed CUG and adequate for gestational age (AGA) children. Serum IGF-I, IGF-II, IGF binding protein-3 and acid-labile subunit were lower in the SGA-CUG children as compared with the other groups. Frequencies of polymorphic variants of vitamin D receptor, estrogen receptor and collagen genes were similar among groups. The genotype 194-192 of the IGF-I gene was higher in the SGA-CUG and 196-192 was higher in the SGA+CUG group. In the SGA-CUG group, the genotype SS of the COLIA1 gene was associated with lower BMD. Therefore, IGF system and COLIA1 polymorphism distinguish prepubertal SGA-CUG children from the SGA+CUG children of the same age. Furthermore, COLIA1 polymorphism could be useful to predict osteopenia in SGA-CUG children.