Iota carrageenan linked barium ion nanoparticle synthesis for the selective targeted imaging and inhibition of cancer cells

• DOI: 10.1515/polyeng-2023-0278
• Publication Date: 2024-03-28T11:20:39Z
• Authors: Aman Shukla; Sachin Kumar; Akanksha Bhatt; Priyank Purohit; Shashank Kailkhura; Magda H. Abdellattif
• Keywords: Barium; Carrageenan

Abstract The development of stable carrageenan nanoparticles connected to the sulfate functional group and barium ion for use selectively targeting cancer cell imaging contrast help with diagnosis (tracing/imaging) is concern present research. This study provides an overview substitution chemistry, highlighting role ions how they affect applicability carrageenan. characteristic sulfate, which widely used as radiopaque provide diagnostic radiographic examinations in gastrointestinal mucosa, provided by its linkage despite K + ’s natural binding additional Ba linked was found highly selective through vitro line assay; however, nonattachability normal makes useful trace treat cell. tracing possible because nanosize molecule, shows precision medicine, fluorescence, X-ray/CT character, be utilized purpose, especially tumor apoptosis from 2+ inhibition outflux disturb osmosis selectivity molecules high pKa (Logarithms acid dissociation constant) value, drug more active anionic (nonpolar) form ionic (polar) cell, avoids interaction facilitate In conclusion, fluorescence properties molecule tracing, imaging, treating selectivity.