Perception, knowledge and protective practices for surgical staff handling antineoplastic drugs during HIPEC and PIPAC

• DOI: 10.1515/pp-2021-0151
• Publication Date: 2022-04-13T15:47:51Z
• Authors: Hubert Benoist; Clarisse Eveno; Sarah Wilson; Nicolas Vigneron; Jean-Marc Guilloit; Rémy Morello; Nicolas Simon; Pascal Odou; Guillaume Saint-L...
• Keywords: R; 610; Specialties of internal medicine; 600; Article; 3. Good health; antineoplastic drugs; 03 medical and health sciences; 0302 clinical medicine; [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication; RC581-951; Medicine; pipac; hipec; occupational risks

Abstract

Objectives Two surgical techniques used for peritoneal metastasis involve a risk of exposure to antineoplastic drugs (ADs): hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC). The objective of this study was to assess the differences in perception, training, and knowledge of the risks as well as in the protection practices and occupational exposures of all worker categories.

Methods This descriptive study, led in two hospitals from two distant French regions, was performed through a face-to-face interview and assessed the perception, knowledge and handling practices of ADs by a questionnaire consisting of 52 questions.

Results Fifty-one professionals participated in this survey. A total of 29.4% (n=15) professionals were afraid to handle ADs. Very few workers have been trained on handling ADs during initial training dedicated to all caregiver (5.9%; n=3). HIPEC is considered to involve a higher risk of exposure to ADs than PIPAC (81.6% (n=31) vs. 57.9% (n=22), respectively, p=0.022, agreement 65.8%). Protective equipment is considered to be less suitable for HIPEC than for PIPAC (29% (n=11) vs. 10.5% (n=4), respectively, p=0.016, agreement 81.6%). Concerning the potential AD contamination location, the participants identified a significant difference between these two practices. During HIPEC, 15.7% (n=6) of caregivers indicated that they had negative symptoms perceived in their practice vs. 2.6% (n=1) during PIPAC.

Conclusions This study shows that perception, knowledge and protection practices are different between HIPEC and PIPAC. It also shows a difference between the worker categories. In view of the difficulties in making operating room staff available, the related training programmes must have an adapted format.