Biological Evaluation of Some Selected Cyclic Imides: Mitochondrial Effects and in vitro Cytotoxicity

• DOI: 10.1515/znc-2004-9-1010
• Publication Date: 2015-02-04T12:59:31Z
• Authors: Silvia Regina Toz...; Valdir Cechinel-F...; Fátima Campos Buzzi; Rogério Corrêa; Silvia Maria Corr...; Maria Benigna Mar...
• Keywords: Imide; Viability assay; Succinimides

Abstract Cyclic imides such as succinimides, maleimides, glutarimides, phthalimides and their derivatives contain an imide ring a general structure -CO-N(R)-CO- that confers hydrophobicity neutral characteristic. A diversity of biological activities pharmaceutical uses have been attributed to them, antibacterial, antifungal, antinociceptive, anticonvulsant, antitumor. In spite these activities, much action mechanisms at molecular cellular levels remain be elucidated. We now show the effects several related cyclic imides: maleimides (S2, S2.1, S2.2, S3), glutarimides (S4, S5, S6), 4-aminoantipyrine (L1, F1, AL1, F1.14, F1.2) sulfonated succinimides (RO1, FA, FE, FD, MC, DMC) on isolated rat liver mitochondria, B16-F10 melanoma cell line, peritoneal macrophages different bacterial streams. The mitochondrial respiratory parameters, viability antibacterial activity were also evaluated. results indicated S3, S5 S6 caused increased oxygen consumption in presence ADP (state III) or its absence IV), while all other compounds decreased those parameters degrees inhibition. All control coefficient (RCC). Loss B16- F10 line was observed, L1 S2.1 being more effective. S1, S2, F1 showed experimental concentrations.