Electrophysiological Correlates of Proactive Control and Binding Processes during Task Switching in Tourette Syndrome

• DOI: 10.1523/eneuro.0279-22.2023
• Publication Date: 2023-04-05T17:50:16Z
• Authors: Laura Wehmeyer; Canan Beate Schüller; Theo O. J. Gruendler; Daniel Huys; Jens Kuhn; Markus Ullsperger; Veerle Visser-Van...; Pablo Andrade; Juan Carlos Balde...; Thomas Schüller
• Keywords: Neurophysiology; Cued speech; Task Switching

Abstract The occurrence of tics in Tourette syndrome (TS) has often been linked to impaired cognitive control, but empirical findings are still inconclusive. A recent view proposes that may be the result an abnormally strong interrelation between perceptual processes and motor actions, commonly referred as perception-action binding. general aim present study was examine proactive control binding effects context task switching adult human patients with TS matched healthy controls. cued paradigm employed 24 (18 male, 6 female) 25 controls while recording electroencephalography (EEG). Residue iteration decomposition (RIDE) applied analyze cue-locked target-locked processes. Behavioral performance unaltered TS. parietal switch positivity, reflecting involved reconfiguration new did not differ groups. Importantly, fronto-central (N2) (P3) modulations, perception action, differed Underlying neurophysiological were best depicted after temporal EEG signal. results argue for altered switching, supporting integration action is processed differently Future studies should further investigate specific conditions under which influence top-down processes, such on bindings.