Distinct Patterns of PV and SST GABAergic Neuronal Activity in the Basal Forebrain during Olfactory-Guided Behavior in Mice

• DOI: 10.1523/jneurosci.0200-24.2025
• Publication Date: 2025-02-18T18:50:23Z
• Authors: Elizabeth H. Moss; Evelyne K. Tantry; Elaine Le; Pey-Shyuan Chin; Priscilla Ambrosi; Katie L. Brandel-...; Benjamin R. Arenkiel
• Keywords: Forebrain

Sensory perception relies on the flexible detection and interpretation of stimuli across variable contexts, conditions, behavioral states. The basal forebrain is a hub for state regulation, supplying dense cholinergic GABAergic projections to various brain regions involved in sensory processing. Of neurons forebrain, parvalbumin (PV) somatostatin (SST) subtypes serve opposing roles towards regulating To elucidate role circuits sensory-guided behavior, we investigated signaling dynamics during odor-guided decision-making male female mice. We used fiber photometry record cell type-specific activity an odor discrimination task correlated temporal patterns PV SST neuronal with olfactory performance. found that while both PV-expressing SST-expressing were excited trial initiation, selectively suppressed by reward whereas excited. Notably, chemogenetic inhibition BF modestly altered decision bias favor reward-seeking optogenetic presentations improved accuracy. Together, these results suggest bidirectional neuron distinctly influence guided behavior. Significance statement This study reveals distinct decision-making. Fiber shows parvalbumin-expressing are rewards, somatostatin-expressing activated, establishing unique recruitment reinforcement. Chemogenetic interventions demonstrate divergent behavior perception. research provides new insights into how shape