High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance

• DOI: 10.1523/jneurosci.0282-08.2008
• Publication Date: 2008-06-11T16:28:15Z
• Authors: A. A. Kuhn; F. Kempf; C. Brucke; L. Gaynor Doyle; I. Martinez-Torres; A. Pogosyan; T. Trottenberg; A. Kupsch; G.-H. Schneider; M. I. Hariz; W. Vandenberghe; B. Nuttin; P. Brown
• Keywords: Subthalamic Nucleus; Local field potential; Beta Rhythm; BETA (programming language); Alpha (finance); Premovement neuronal activity

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson9s disease (PD), but its mechanism action unclear. Exaggerated oscillatory synchronization in β (13–30 Hz) frequency band has been associated bradykinesia PD. Accordingly, we tested hypothesis that clinical benefit exerted by STN HFS accompanied suppression local activity. To this end, explored after effects on field potential (LFP) activity recorded from immediately cessation 11 PD patients. Only demonstrated temporary persistence were analyzed. led to significant reduction LFP 12 s end and decrease motor cortical–STN coherence over same time period. The correlated movement amplitude during simple task, so smaller amount was better task performance. These features absent when power 5–12 Hz considered. Our findings suggest may act modulating pathological patterns synchronized oscillations, specifically