Dopamine Supports Coupling of Attention-Related Networks

• DOI: 10.1523/jneurosci.0909-12.2012
• Publication Date: 2012-08-01T18:06:12Z
• Authors: L. C. Dang; J. P. O'Neil; W. J. Jagust
• Keywords: Task-positive network; Neurochemical; Attention network; Attentional control

Attentional processing has been associated with the dorsal attention, default mode, and frontoparietal control networks. The attention network is involved in externally focused whereas mode internally directed attention. proposed to mediate transition between external internal by coupling its activity either or network, depending on attentional demand. Dopamine hypothesized modulate linked integrity of these three attention-related We used PET 6-[¹⁸F]fluoro-L-m-tyrosine quantify dopamine synthesis capacity <i>in vivo</i> fMRI acquire stimulus-independent brain cognitively healthy human subjects. found that resting state where cognition dominates, enhances while reducing network. These results add a neurochemical perspective role interaction modulating