Genes Associated with Adult Axon Regeneration Promoted by Olfactory Ensheathing Cells: A New Role for Matrix Metalloproteinase 2

• DOI: 10.1523/jneurosci.1111-06.2006
• Publication Date: 2006-05-18T00:19:27Z
• Authors: Erika Pastrana; Maria Teresa More...; Esteban N. Gurzov; Jesus Avila; Francisco Wandosell; Javier Diaz-Nido
• Keywords: Olfactory ensheathing glia; Muller glia

The molecular mechanisms used by olfactory ensheathing cells (OECs) to promote repair in the damaged adult mammalian CNS remain unknown. Thus, we microarrays analyze three OEC populations with different capacities axonal regeneration cultured rat retinal neurons. Gene expression “long-term OECs” that do not stimulate outgrowth was compared of “primary cells” and immortalized cell line TEG3. In this way, identified a number candidate genes might play role promoting regeneration. Among these genes, it striking both matrix metalloproteinase 2 (MMP2) an inhibitor protease were represented. disruption MMP2 activity TEG3 impaired their capacity trigger axon Furthermore, protein detected grafts OECs elicited robust injured spinal cord rats vivo . These data suggest does indeed participate induced OECs.