Hippocampus–Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination

Male 570 hippocampus 1.2 Psychological and socioeconomic processes 1.1 Normal biological development and functioning 150 Prefrontal Cortex 32 Biomedical and Clinical Sciences Prefrontal cortex Basic Behavioral and Social Science Hippocampus context novelty memory Discrimination Learning Rats, Sprague-Dawley 03 medical and health sciences anzsrc-for: 32 Biomedical and Clinical Sciences Memory Behavioral and Social Science Neural Pathways Psychology Animals anzsrc-for: 17 Psychology and Cognitive Sciences 280102 - Expanding knowledge in the biological sciences Neurons prefrontal cortex 0303 health sciences 320903 - Central nervous system Context Neurosciences Novelty Recognition, Psychology 004 Brain Disorders Rats Recognition Mental Health anzsrc-for: 11 Medical and Health Sciences 3209 Neurosciences Neurological anzsrc-for: 3209 Neurosciences Sprague-Dawley recognition
DOI: 10.1523/jneurosci.1202-21.2021 Publication Date: 2021-10-12T21:07:51Z
ABSTRACT
Recognition memory provides the ability to distinguish familiar from novel objects and places, is important for recording updating events guide appropriate behavior. The hippocampus (HPC) medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but nature of HPC-mPFC interactions, its impact on local circuits mediating this process not known. Here we show that novelty discrimination accompanied with higher theta activity (4-10 Hz) increased c-Fos expression these regions. Moreover, oscillations were highly coupled between HPC mPFC during retrieval discrimination, leading mPFC, initial learning. Principal neurons interneurons responded more strongly compared Optogenetic silencing input disrupted two structures, as well animals' (male Sprague Dawley rats) differentiate objects. These results reveal a key role monosynaptic connections via coupling identify neural populations underlie memory-guided behavior.SIGNIFICANCE STATEMENT Many processes are dependent interregional communication oscillations. However, how brain regions coordinate their oscillatory engage mediate poorly understood. This study revealed temporal correlated During object recognition, drives effectively reduce principal neurons. first evidence requirement pathway describes mechanism regulated.
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