Hippocampus–Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination
Male
570
hippocampus
1.2 Psychological and socioeconomic processes
1.1 Normal biological development and functioning
150
Prefrontal Cortex
32 Biomedical and Clinical Sciences
Prefrontal cortex
Basic Behavioral and Social Science
Hippocampus
context
novelty
memory
Discrimination Learning
Rats, Sprague-Dawley
03 medical and health sciences
anzsrc-for: 32 Biomedical and Clinical Sciences
Memory
Behavioral and Social Science
Neural Pathways
Psychology
Animals
anzsrc-for: 17 Psychology and Cognitive Sciences
280102 - Expanding knowledge in the biological sciences
Neurons
prefrontal cortex
0303 health sciences
320903 - Central nervous system
Context
Neurosciences
Novelty
Recognition, Psychology
004
Brain Disorders
Rats
Recognition
Mental Health
anzsrc-for: 11 Medical and Health Sciences
3209 Neurosciences
Neurological
anzsrc-for: 3209 Neurosciences
Sprague-Dawley
recognition
DOI:
10.1523/jneurosci.1202-21.2021
Publication Date:
2021-10-12T21:07:51Z
AUTHORS (10)
ABSTRACT
Recognition memory provides the ability to distinguish familiar from novel objects and places, is important for recording updating events guide appropriate behavior. The hippocampus (HPC) medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but nature of HPC-mPFC interactions, its impact on local circuits mediating this process not known. Here we show that novelty discrimination accompanied with higher theta activity (4-10 Hz) increased c-Fos expression these regions. Moreover, oscillations were highly coupled between HPC mPFC during retrieval discrimination, leading mPFC, initial learning. Principal neurons interneurons responded more strongly compared Optogenetic silencing input disrupted two structures, as well animals' (male Sprague Dawley rats) differentiate objects. These results reveal a key role monosynaptic connections via coupling identify neural populations underlie memory-guided behavior.SIGNIFICANCE STATEMENT Many processes are dependent interregional communication oscillations. However, how brain regions coordinate their oscillatory engage mediate poorly understood. This study revealed temporal correlated During object recognition, drives effectively reduce principal neurons. first evidence requirement pathway describes mechanism regulated.
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CITATIONS (52)
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