Hippocampus–Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination

• DOI: 10.1523/jneurosci.1202-21.2021
• Publication Date: 2021-10-12T21:07:51Z
• Authors: Cong Wang; Teri M. Furlong; Peter G. Stratton; Conrad C. Y. Lee; Li Xu; Sam Merlin; Chris Nolan; Ehsan Arabzadeh; Roger Marek; Pankaj Sah
• Keywords: Male; 0301 basic medicine; 570; hippocampus; 1.2 Psychological and socioeconomic processes; 1.1 Normal biological development and functioning; 150; Prefrontal Cortex; 32 Biomedical and Clinical Sciences; Prefrontal cortex; Basic Behavioral and Social Science; Hippocampus; context; novelty; memory; Discrimination Learning; Rats, Sprague-Dawley; 03 medical and health sciences; anzsrc-for: 32 Biomedical and Clinical Sciences; Memory; Behavioral and Social Science; Neural Pathways; Psychology; Animals; anzsrc-for: 17 Psychology and Cognitive Sciences; 280102 - Expanding knowledge in the biological sciences; Neurons; prefrontal cortex; 0303 health sciences; 320903 - Central nervous system; Context; Neurosciences; Novelty; Recognition, Psychology; 004; Brain Disorders; Rats; Recognition; Mental Health; anzsrc-for: 11 Medical and Health Sciences; 3209 Neurosciences; Neurological; anzsrc-for: 3209 Neurosciences; Sprague-Dawley; recognition

Recognition memory provides the ability to distinguish familiar from novel objects and places, is important for recording updating events guide appropriate behavior. The hippocampus (HPC) medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but nature of HPC-mPFC interactions, its impact on local circuits mediating this process not known. Here we show that novelty discrimination accompanied with higher theta activity (4-10 Hz) increased c-Fos expression these regions. Moreover, oscillations were highly coupled between HPC mPFC during retrieval discrimination, leading mPFC, initial learning. Principal neurons interneurons responded more strongly compared Optogenetic silencing input disrupted two structures, as well animals' (male Sprague Dawley rats) differentiate objects. These results reveal a key role monosynaptic connections via coupling identify neural populations underlie memory-guided behavior.SIGNIFICANCE STATEMENT Many processes are dependent interregional communication oscillations. However, how brain regions coordinate their oscillatory engage mediate poorly understood. This study revealed temporal correlated During object recognition, drives effectively reduce principal neurons. first evidence requirement pathway describes mechanism regulated.