Hippocampus–Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination
Male
0301 basic medicine
570
hippocampus
1.2 Psychological and socioeconomic processes
1.1 Normal biological development and functioning
150
Prefrontal Cortex
32 Biomedical and Clinical Sciences
Prefrontal cortex
Basic Behavioral and Social Science
Hippocampus
context
novelty
memory
Discrimination Learning
Rats, Sprague-Dawley
03 medical and health sciences
anzsrc-for: 32 Biomedical and Clinical Sciences
Memory
Behavioral and Social Science
Neural Pathways
Psychology
Animals
anzsrc-for: 17 Psychology and Cognitive Sciences
280102 - Expanding knowledge in the biological sciences
Neurons
prefrontal cortex
0303 health sciences
320903 - Central nervous system
Context
Neurosciences
Novelty
Recognition, Psychology
004
Brain Disorders
Rats
Recognition
Mental Health
anzsrc-for: 11 Medical and Health Sciences
3209 Neurosciences
Neurological
anzsrc-for: 3209 Neurosciences
Sprague-Dawley
recognition
DOI:
10.1523/jneurosci.1202-21.2021
Publication Date:
2021-10-12T21:07:51Z
AUTHORS (10)
ABSTRACT
Recognition memory provides the ability to distinguish familiar from novel objects and places, and is important for recording and updating events to guide appropriate behavior. The hippocampus (HPC) and medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but the nature of HPC–mPFC interactions, and its impact on local circuits in mediating this process is not known. Here we show that novelty discrimination is accompanied with higher theta activity (4–10 Hz) and increased c-Fos expression in both these regions. Moreover, theta oscillations were highly coupled between the HPC and mPFC during recognition memory retrieval for novelty discrimination, with the HPC leading the mPFC, but not during initial learning. Principal neurons and interneurons in the mPFC responded more strongly during recognition memory retrieval compared with learning. Optogenetic silencing of HPC input to the mPFC disrupted coupled theta activity between these two structures, as well as the animals' (male Sprague Dawley rats) ability to differentiate novel from familiar objects. These results reveal a key role of monosynaptic connections between the HPC and mPFC in novelty discrimination via theta coupling and identify neural populations that underlie this recognition memory-guided behavior.SIGNIFICANCE STATEMENTMany memory processes are highly dependent on the interregional communication between the HPC and mPFC via neural oscillations. However, how these two brain regions coordinate their oscillatory activity to engage local neural populations to mediate recognition memory for novelty discrimination is poorly understood. This study revealed that the HPC and mPFC theta oscillations and their temporal coupling is correlated with recognition memory-guided behavior. During novel object recognition, the HPC drives mPFC interneurons to effectively reduce the activity of principal neurons. This study provides the first evidence for the requirement of the HPC–mPFC pathway to mediate recognition memory for novelty discrimination and describes a mechanism for how this memory is regulated.
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CITATIONS (52)
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