Purinergic Receptor-Stimulated IP3-Mediated Ca2+ Release Enhances Neuroprotection by Increasing Astrocyte Mitochondrial Metabolism during Aging

• DOI: 10.1523/jneurosci.1256-07.2007
• Publication Date: 2007-06-14T05:09:30Z
• Authors: J. Wu; J. D. Holstein; G. Upadhyay; D.-T. Lin; S. Conway; E. Muller; J. D. Lechleiter
• Keywords: Inositol trisphosphate receptor; Oligomycin; P2Y receptor

Astrocytes play an essential role in the maintenance and protection of brain, which we reported was diminished with age. Here, demonstrate that activation a purinergic receptor (P2Y-R) signaling pathway, astrocytes, significantly increases resistance astrocytes neurons to oxidative stress. Interestingly, P2Y-R old increased their stress levels were comparable stimulated young astrocytes. enhanced neuroprotection blocked by oligomycin Xestospongin C, inhibitors ATP synthase inositol (1,4,5) triphosphate (IP3) binding IP3 receptor, respectively. Treatment membrane permeant analog also protected against These data indicate astrocyte is mediated Ca2+-dependent increase mitochondrial metabolism. reveal pathway can rapidly respond central energy needs throughout aging process.