Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex

• DOI: 10.1523/jneurosci.1290-18.2018
• Publication Date: 2018-09-24T17:55:25Z
• Authors: Eirik S. Nilssen; Bente Jacobsen; Gunhild Fjeld; Rajeevkumar R. Nair; Stefan Blankvoort; Clifford Kentros; Menno P. Witter
• Keywords: Entorhinal cortex; Hepatic stellate cell; Cell type

Fan cells in layer II of the lateral entorhinal cortex (LEC) form a main component projection to dentate gyrus, CA3 and CA2 hippocampal formation. This has counterpart originating from stellate medial (MEC). Available evidence suggests that two pathways carry different information, exemplified by difference spatial tuning LEC MEC. The grid cell, prominent position-modulated cell type present MEC, been postulated derive its characteristic hexagonal firing pattern dominant disynaptic inhibitory connections between hippocampal-projecting cells. Given have not described LEC, we aim describe local synaptic connectivity fan cells, explore whether network architecture is similar MEC cell. Using combination vitro multicell electrophysiological optogenetic approaches acute slices rodents either sex, show excitatory very sparse. connect preferentially with distinct types interneurons, suggesting coupling as communication among These principles are those reported for indicating an overall comparable circuit cortex. SIGNIFICANCE STATEMENT Our data provide first description microcircuit We these make infrequent monosynaptic each other, they communicate through network. cortex, but dissimilar observed 2 neocortex. In structure proposed underlie opens possibility exhibit regular patterns unexplored domain.