Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase

• DOI: 10.1523/jneurosci.15-08-05486.1995
• Publication Date: 2018-04-02T18:20:40Z
• Authors: H Moreno; C Kentros; E Bueno; M Weiser; A Hernandez; E Vega-Saenz de M...; A Ponce; W Thornhill; B Rudy
• Keywords: Heterologous expression

The finding that some K+ channel mRNAs are restricted to certain populations of neurons in the CNS suggests there channels tailored neuronal circuits. One such example transcripts from KV3.2 gene, majority which expressed thalamic relay neurons. To gain insights into specific roles subunits, site antibodies were raised determine their localization Immunohistochemical and focal lesioning studies demonstrate proteins localized terminal fields thalamocortical projections. It is also shown vitro strongly inhibited through phosphorylation by cAMP-dependent protein kinase (PKA). Channels containing KV3.1 otherwise exhibit nearly identical electrophysiological properties heterologous expression systems but have a different less pattern CNS, not affected PKA. Therefore, this modulation might be associated with subunits. Furthermore, we can phosphorylated situ intrinsic subunits display consistent role regulation efficacy synapse, could thereby participate neurotransmitter-mediated control functional states system global awareness.