A Family of Activity-Dependent Neuronal Cell-Surface Chondroitin Sulfate Proteoglycans in Cat Visual Cortex

• DOI: 10.1523/jneurosci.17-06-01928.1997
• Publication Date: 2018-04-02T21:55:32Z
• Authors: Cynthia Lander; Peter Kind; Michael Maleski; Susan Hockfield
• Keywords: Chondroitin sulfate proteoglycan; Perineuronal net

Monoclonal antibody Cat-301 recognizes a chondroitin sulfate proteoglycan (CSPG) expressed on the extracellular surface of cell bodies and proximal dendrites specific subsets neurons in many areas mammalian CNS, including cat visual cortex. The CSPG is first detected at close critical period development, during which pattern neuronal activity determines mature synaptic circuitry phenotype. In cortex, dark-rearing from birth prolongs duration attenuates expression antigen, implicating cellular mechanisms that terminate plasticity. Because antigen only limited subset neurons, we have further examined molecular heterogeneity among cell-surface CSPGs asked (1) whether other carry distinct (2) activity-dependent property generalizable to related CSPGs. Here, report two new monoclonal antibodies, Cat-315 Cat-316, together with define family least seven yet These three antibodies nonidentical normal levels these reduced by dark-rearing. Together, data show molecularly diverse, different sets express complements antigens, regulation may be general feature