BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development
Neurons
0303 health sciences
Brain-Derived Neurotrophic Factor
Gene Expression Profiling
TOR Serine-Threonine Kinases
Brain
Dendrites
Rats
Phosphatidylinositol 3-Kinases
03 medical and health sciences
Gene Expression Regulation
Homer Scaffolding Proteins
Polyribosomes
Protein Biosynthesis
Synapses
Animals
Rats, Long-Evans
RNA, Messenger
Carrier Proteins
Protein Kinases
Signal Transduction
DOI:
10.1523/jneurosci.1739-04.2004
Publication Date:
2004-08-18T18:51:44Z
AUTHORS (5)
ABSTRACT
Local regulation of mRNA translation plays an important role in axon guidance, synaptic development, and neuronal plasticity. Little is known, however, regarding the mechanisms that control neurons, only a few mRNAs have been identified are locally translated within dendrites. Using Affymetrix gene arrays to identify newly associated with polysomes after exposure BDNF, we subsets for which enhanced neurons at different developmental stages. In mature many these encode proteins known function synapses, including CamKIIalpha, NMDA receptor subunits, postsynaptic density (PSD) scaffolding protein Homer2. BDNF regulates Homer2 synaptodendritic compartment by activating translational initiation via mammalian target rapamycin-phosphatidylinositol 3-kinase-dependent pathway. These findings suggest likely inducing local synthesis numerous proteins. The cytoskeleton-associated particular might implications growth cone dynamics dendritic spine development.
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