Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice
Neurons
0301 basic medicine
Cell Survival
Cranial Nerves
Brain
Apoptosis
Embryo, Mammalian
Embryonic and Fetal Development
Mice
03 medical and health sciences
Animals, Newborn
Proto-Oncogene Proteins c-bcl-2
Spinal Cord
Ganglia, Spinal
Proto-Oncogene Proteins
Animals
Ganglia
Atrophy
Neuroglia
bcl-2-Associated X Protein
DOI:
10.1523/jneurosci.18-04-01428.1998
Publication Date:
2018-04-03T03:05:41Z
AUTHORS (5)
ABSTRACT
The proapoptotic molecule BAX is required for death of sympathetic and motor neurons in the setting trophic factor deprivation. Furthermore, adult Bax−/− mice have more than do their wild-type counterparts. These findings raise possibility that regulates naturally occurring cell during development many neuronal populations. To test this idea, we assessed apoptosis using TUNEL labeling several well-studied neural systems embryonic early postnatal mice. Remarkably, virtually eliminated between day 11.5 (E11.5) 1 (PN1) most peripheral ganglia, pools spinal cord, trigeminal brainstem nuclear complex. Additionally, reduction, although not elimination, was noted throughout developing cerebellum, some layers retina, hippocampus. Saving cells verified by axon counts dorsal ventral roots, as well facial optic nerves revealed 24–35% increases number. Interestingly, supernumerary axons had very small cross-sectional areas, suggesting associated are normal. We conclude a critical mediator CNS life. However, rescue from does imply will develop normal functional capabilities.
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