Accumulation ofF-Spondinin Injured Peripheral Nerve Promotes the Outgrowth of Sensory Axons

• DOI: 10.1523/jneurosci.18-21-08875.1998
• Publication Date: 2018-04-03T02:35:40Z
• Authors: Tal Burstyn-Cohen; Ayala Frumkin; Yi-Tian Xu; Steven S. Scherer; Avihu Klar
• Keywords: Axotomy; Neurite; Growth cone

F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation both F-spondin mRNA and protein distal to the lesion. stump axotomized promotes neurite outgrowth sensory neurons, as revealed neutralization with F-spondin-specific antibodies. Thus, likely play role promoting axonal regeneration after injury.