p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure

• DOI: 10.1523/jneurosci.19-16-06887.1999
• Publication Date: 2018-04-13T22:21:07Z
• Authors: Philippe P. Roux; Michael A. Colicos; Philip A. Barker; Timothy E. Kennedy
• Keywords: Piriform cortex; NeuN; Entorhinal cortex; Terminal deoxynucleotidyl transferase

Seizure causes neuronal cell loss in both animal models and human epilepsy. To determine the contribution of apoptotic mechanisms to seizure-induced death, rat brains were examined for occurrence terminal deoxynucleotidyl transferase-mediated UTP nick end labeling (TUNEL)-positive nuclei after pilocarpine-induced seizure. Numerous TUNEL-positive cells observed throughout postseizure hippocampus, piriform cortex, entorhinal cortex. Combined TUNEL/NeuN immunocytochemistry demonstrated that vast majority neurons. identify components signal transduction cascade promoting apoptosis, expression p75 neurotrophin receptor (p75NTR) was examined. Seizure-induced increases p75NTR protein mRNA detected Immunohistochemical double revealed almost complete correspondence between p75NTR-expressing cells, suggesting within CNS occurs through signaling cascades involving p75NTR.