Differences in Expression of Acetylcholinesterase and Collagen Q Control the Distribution and Oligomerization of the Collagen-Tailed Forms in Fast and Slow Muscles

• DOI: 10.1523/jneurosci.19-24-10672.1999
• Publication Date: 2018-04-07T01:15:57Z
• Authors: Eric Krejci; Claire Legay; Sébastien Thomine; Janez Sketelj; Jean Massoulié
• Keywords: Male; 0301 basic medicine; Xenopus; Muscle Proteins; Rats; 03 medical and health sciences; Muscle Fibers, Slow-Twitch; Neck Muscles; Muscle Fibers, Fast-Twitch; Acetylcholinesterase; Oocytes; Animals; Tissue Distribution; Collagen; RNA, Messenger; Muscle, Skeletal; Protein Processing, Post-Translational

The collagen-tailed forms of acetylcholinesterase (AChE) are accumulated at mammalian neuromuscular junctions. A 4 , 8 and 12 expressed differently in the rat fast slow muscles; sternomastoid muscle contains essentially form end plates, whereas soleus also extrajunctional forms. We show that collagen Q (ColQ) transcripts become exclusively junctional adult but remain uniformly soleus. By coinjecting Xenopus oocytes with AChE T ColQ mRNAs, we reproduced patterns ColQ1 ColQ1a, only ColQ1a. Collagen-tailed represents first evidence synaptic components involved cholinergic transmission may be regulated muscles.