Left Anterior Temporal Lobe and Bilateral Anterior Cingulate Cortex Are Semantic Hub Regions: Evidence from Behavior-Nodal Degree Mapping in Brain-Damaged Patients

• DOI: 10.1523/jneurosci.1946-16.2016
• Publication Date: 2016-11-16T13:18:47Z
• Authors: Ying Zhao; Luping Song; Junhua Ding; Nan Lin; Qiang Wang; Xiaoxia Du; Rong Sun; Zaizhu Han
• Keywords: Degree (music); Cingulate cortex; Lobe

The organizational principles of semantic memory in the human brain are still controversial. Although studies have shown that system contains hub regions bind information from different sensorimotoric modalities to form concepts, it is unknown whether there other than anterior temporal lobe (ATL). Meanwhile, previous rarely used network measurements explore hubs or correlated indexes with performance, although most direct supportive evidence should come perspective. To fill this gap, we brain-network index performance 86 brain-damaged patients. We especially selected nodal degree measure reflects how well a node connected network. was calculated as total number connections given nodes resting-state functional MRI Semantic ability measured using both general and modality-specific (object form, color, motion, sound, manipulation, function) tasks. found left ATL bilateral cingulate cortex could be because reduced values these effectively predict deficits performance. Moreover, effects remained when analyses were performed only patients who did not lesions regions. two might support representations executive control processes, respectively. These data provide empirical for distributed-plus-hub theory SIGNIFICANCE STATEMENT organization has been proposed several years, remains unclear which included system. Here, identified such an innovative voxelwise tasks damage. observed their decreased significantly severity deficit contribute representational findings offer new theory.