p75 Is Important for Axon Growth and Schwann Cell Migration during Development

• DOI: 10.1523/jneurosci.20-20-07706.2000
• Publication Date: 2018-04-05T02:45:48Z
• Authors: Cornelia A. Bentley; Kuo-Fen Lee
• Keywords: Neurite; Schwann cell; Dorsal root ganglion; Trigeminal ganglion

Mice lacking the low-affinity neurotrophin receptor p75 have multiple peripheral neural deficits. Here we examined developmental nature of these deficiencies. Peripheral axons in -/- embryos were severely stunted and poorly arborized from embryonic day 11.5 (E11.5) to E14.5. In vitro, neurite outgrowth dorsal root ganglia was significantly decreased at E12.5, suggesting that axonal growth embryo may result part defects elongation. Additionally, Schwann cell marker S100beta immunoreactivity or absent along growing ophthalmic branch trigeminal embryos. Electron microscopy studies ganglion E13.5 revealed mutant embryo, nerve bundles highly impaired coverage by cytoplasm substantially reduced. migration lack staining results a deficit migration. These provide evidence is important developing for regulating axon arborization