Late Oligodendrocyte Progenitors Coincide with the Developmental Window of Vulnerability for Human Perinatal White Matter Injury

• DOI: 10.1523/jneurosci.21-04-01302.2001
• Publication Date: 2018-04-05T00:12:27Z
• Authors: Stephen A. Back; Ning Ling Luo; Natalya S. Borens...; Joel M. Levine; Joseph J. Volpe; Hannah C. Kinney
• Keywords: Periventricular leukomalacia

Hypoxic-ischemic injury to the periventricular cerebral white matter [periventricular leukomalacia (PVL)] results in palsy and is leading cause of brain premature infants. The principal feature PVL a chronic disturbance myelination suggests that oligodendrocyte (OL) lineage progression disrupted by ischemic injury. We determined OL stages at risk for during developmental window vulnerability (23-32 weeks, postconceptional age). In 26 normal control autopsy human brains, was defined parietal matter, region predilection PVL. Three successive stages, late progenitor, immature OL, mature were characterized between 18 41 weeks with anti-NG2 proteoglycan, O4, O1, anti-myelin basic protein (anti-MBP) antibodies. NG2+O4+ progenitors predominant stage throughout latter half gestation. Between 27 O4+O1+ OLs minor population (9.9 +/- 2.1% total OLs; n = 9). 28 an increase 30.9 (n 9) accompanied progressive MBP+ myelin sheaths restricted matter. high thus precedes onset identifies progenitor as major potential target. Moreover, decline incidence approximately 32 coincides related presence