Dopaminergic Role in Stimulant-Induced Wakefulness

• DOI: 10.1523/jneurosci.21-05-01787.2001
• Publication Date: 2018-04-06T18:26:24Z
• Authors: Jonathan P. Wisor; Seiji Nishino; Ichiro Sora; George H. Uhl; Emmanuel Mignot; Dale M. Edgar
• Keywords: Stimulant; Methamphetamine

The role of dopamine in sleep regulation and mediating the effects wake-promoting therapeutics is controversial. In this study, polygraphic recordings caudate microdialysate measurements narcoleptic dogs revealed that antinarcoleptic compounds modafinil amphetamine increase extracellular a hypocretin receptor 2-independent manner. mice, deletion transporter (DAT) gene reduced non-rapid eye movement time increased wakefulness consolidation independently from locomotor effects. DAT knock-out mice were also unresponsive to normally robust action modafinil, methamphetamine, selective blocker GBR12909 but hypersensitive caffeine. Thus, transporters play an important are necessary for specific amphetamines modafinil.