Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice

• DOI: 10.1523/jneurosci.21-23-09499.2001
• Publication Date: 2018-04-05T22:38:16Z
• Authors: Andreas Zimmer; Emmanuel Valjent; Monika König; Anne M. Zimmer; Patricia Robledo; Heidi Hahn; Olga Valverde; Rafael Maldonado
• Keywords: Dynorphin; Tetrahydrocannabinol; Endogenous opioid; Dynorphin A; Δ9-tetrahydrocannabinol

The involvement of dynorphin on Δ-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation the prodynorphin (<i>Pdyn</i>) gene. Dynorphin-deficient show specific changes in behavioral effects THC, including reduction spinal THC analgesia absence THC-induced conditioned place aversion. In contrast, acute chronic opioid were normal. lack negative motivational demonstrates that this endogenous peptide mediates dysphoric marijuana.